Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 4/20 | 0.44 |
| ▸ | ABL1 | P00519 | 4/20 | 0.43 |
| ▸ | BCR | P11274 | 4/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190849 | 1.00 | RAB9A (0.46) | RAB9AWDR5ABL1BCRGALR3 | |
| SCHEMBL30114750 | 0.93 | ABL1 (0.47) | ABL1BCRLMNAEGFRGSK3B | |
| SCHEMBL20190739 | 0.93 | ABL1 (0.47) | ABL1BCRLMNAEGFRGSK3B | |
| SCHEMBL21799082 | 0.91 | RAB9A (0.47) | RAB9AWDR5GALR3LMNAMAPT | |
| SCHEMBL30114860 | 0.91 | RAB9A (0.47) | RAB9AWDR5GALR3LMNAMAPT | |
| SCHEMBL21799042 | 0.90 | ABL1 (0.51) | RAB9AABL1BCRGALR3LMNA | |
| SCHEMBL30114678 | 0.90 | ABL1 (0.51) | RAB9AABL1BCRGALR3LMNA | |
| SCHEMBL30530275 | 0.87 | ABL1 (0.47) | RAB9AWDR5ABL1 | |
| SCHEMBL20188432 | 0.87 | ABL1 (0.47) | RAB9AWDR5ABL1 | |
| SCHEMBL30530278 | 0.86 | RAB9A (0.49) | RAB9AWDR5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | claimed |
| CN-110139692-B | Heteroaryl amine compounds for modulating hedgehog pathway and methods of making and using the same | 财团法人生物技术开发中心 | 2023-08-25 | — | — | CN | disclosed |
| EP-3544685-B1 | HETROARYLAMINE COMPOUNDS FOR MODULATING THE HEDGEHOG PATHWAY AND PREPARING METHOD AND USES THEREOF | DEV CT BIOTECHNOLOGY (TW) | 2023-01-04 | — | — | EP | disclosed |