Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506789 | 1.00 | CCR1 (0.48) | CCR1CCR8CYP2A6METAP2GAA | |
| SCHEMBL1194066 | 0.75 | BTK (0.58) | CCR1CCR8METAP2GAAMAPT | |
| SCHEMBL309114 | 0.74 | CCR1 (0.54) | CCR1CCR8CYP2A6METAP2KMT2A | |
| SCHEMBL29627866 | 0.72 | PDE3B (0.33) | KMT2APDE3BPDE3A | |
| SCHEMBL26289617 | 0.72 | PDE3B (0.33) | KMT2APDE3BPDE3A | |
| SCHEMBL14919456 | 0.72 | RAB9A (0.53) | GAAMAPTKMT2AKDM4EHPGD | |
| SCHEMBL15131529 | 0.71 | CCR1 (0.50) | CCR1CCR8CYP2A6METAP2TGFBR1 | |
| SCHEMBL18036062 | 0.71 | GAA (0.44) | CCR1CCR8GAAMAPTKMT2A | |
| SCHEMBL2128866 | 0.71 | CYP2A6 (0.42) | CCR1CCR8CYP2A6METAP2MAPT | |
| SCHEMBL2128871 | 0.71 | CCR1 (0.42) | CCR1CCR8CYP2A6METAP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443269-A | Substituted pyrimidines and methods of use | 施万生物制药研发IP有限责任公司 | 2022-12-06 | — | — | CN | disclosed |