Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 13/20 | 0.53 |
| ▸ | NPC1 | O15118 | 12/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | PKM | P14618 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651969 | 0.76 | ALDH1A1 (0.59) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL27986687 | 0.75 | RAB9A (0.50) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL1194066 | 0.74 | BTK (0.58) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL26989943 | 0.73 | NPC1 (0.47) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL31295402 | 0.73 | NPC1 (0.56) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL30114941 | 0.72 | CCR1 (0.48) | KDM4EHSD17B10HPGDKMT2AMAPT | |
| SCHEMBL6506789 | 0.72 | CCR1 (0.48) | KDM4EHSD17B10HPGDKMT2AMAPT | |
| SCHEMBL29627866 | 0.71 | PDE3B (0.33) | MEN1KMT2AHIF1AMAPK1 | |
| SCHEMBL26289617 | 0.71 | PDE3B (0.33) | MEN1KMT2AHIF1AMAPK1 | |
| SCHEMBL4811458 | 0.71 | RAB9A (0.57) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2773207-A1 | AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-09-10 | — | — | EP | disclosed |
| WO-2013066729-A1 | AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-05-10 | — | — | WO | disclosed |