Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | UGCG | Q16739 | 3/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792207 | 0.83 | CYP19A1 (0.42) | POLBGRM5CYP19A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL329787 | 0.76 | ADRA1A (0.33) | CYP19A1HTR2C | |
| SCHEMBL33530704 | 0.74 | PARP10 (0.36) | GRM5GRM1KDM4EALDH1A1HTR2C | |
| SCHEMBL2301748 | 0.68 | SCN9A (0.36) | SCN9AKDM4EMEN1USP2ALDH1A1 | |
| SCHEMBL15319609 | 0.68 | MRGPRX4 (0.53) | POLBRECQLHDAC1HDAC6HDAC5 | |
| SCHEMBL7338667 | 0.68 | KDM4E (0.54) | SCN9AKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL15335809 | 0.64 | RXRA (0.49) | KDM4EMEN1USP2ALDH1A1HSP90AA1 | |
| SCHEMBL1010644 | 0.63 | METAP1 (0.37) | GRM5GRM1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3063291 | 0.63 | SMN1; SMN2 (0.47) | GRM5GRM1CYP19A1ALDH1A1 | |
| SCHEMBL14961675 | 0.62 | CD44 (0.47) | HDAC1HDAC6HDAC5MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143165-A1 | SPIROUREA DERIVATIVES | Idorsia Pharmaceuticals Ltd (CH) | 2023-03-08 | — | — | EP | disclosed |
| CN-115461327-A | Spiro urea derivatives | 爱杜西亚药品有限公司 | 2022-12-09 | — | — | CN | disclosed |