Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 6/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19643748 | 1.00 | CREBBP (0.55) | CREBBPRIPK1MAPK1ESR2NR1H2 | |
| SCHEMBL19644450 | 0.88 | CREBBP (0.55) | CREBBPRIPK1MAPK1ESR2NR1H2 | |
| SCHEMBL19643780 | 0.83 | CREBBP (0.76) | CREBBP | |
| SCHEMBL3276575 | 0.83 | CREBBP (0.54) | CREBBPRIPK1MAPK1 | |
| SCHEMBL3279644 | 0.81 | MAPK1 (0.49) | CREBBPMAPK1ESR2NR1H2UCHL1 | |
| SCHEMBL20565298 | 0.79 | RIPK1 (0.67) | RIPK1MAPK1ESR2NR1H2LMNA | |
| SCHEMBL2986290 | 0.79 | MAPK1 (0.50) | RIPK1MAPK1ESR2NR1H2LMNA | |
| SCHEMBL16461039 | 0.78 | ESR2 (0.44) | CREBBPRIPK1MAPK1ESR2NR1H2 | |
| SCHEMBL8485212 | 0.76 | NR1H2 (0.62) | CREBBPMAPK1ESR2NR1H2UCHL1 | |
| SCHEMBL3283796 | 0.76 | UCHL1 (0.52) | CREBBPMAPK1ESR2NR1H2UCHL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4067347-A1 | HETEROCYCLIC INHIBITORS OF CBP/EP300 FOR THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2022-10-05 | — | — | EP | disclosed |