Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22954280 | 1.00 | GRM4 (0.51) | GRM4MAP4K4DRD1GRM5KDM4E | |
| SCHEMBL17099766 | 0.88 | GRM5 (0.42) | GRM4MAP4K4GRM5KDM4ENPC1 | |
| SCHEMBL8252632 | 0.84 | GABRA1 (0.54) | MAP4K4GRM5KDM4ENPC1PKM | |
| SCHEMBL21816566 | 0.81 | CYP1A2 (0.54) | GRM4DRD1KDM4ENPC1PKM | |
| SCHEMBL17500184 | 0.81 | GRM5 (0.49) | MAP4K4GRM5KDM4ENPC1PKM | |
| SCHEMBL31187765 | 0.81 | GRM5 (0.49) | MAP4K4GRM5KDM4ENPC1PKM | |
| SCHEMBL17100103 | 0.81 | GRM5 (0.67) | GRM5KCNH2 | |
| SCHEMBL23526602 | 0.80 | GRM5 (0.48) | MAP4K4GRM5KDM4ENPC1PKM | |
| SCHEMBL31083655 | 0.80 | GRM5 (0.48) | MAP4K4GRM5KDM4ENPC1PKM | |
| SCHEMBL4121987 | 0.79 | CNR1 (0.67) | GRM4KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |