Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 11/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15637975 | 1.00 | TGFBR1 (0.51) | TGFBR1TRPA1MAPKAPK2KDM4EMEN1 | |
| SCHEMBL15639196 | 0.88 | TGFBR1 (0.53) | TGFBR1TRPA1TRPM8 | |
| SCHEMBL15639499 | 0.88 | TGFBR1 (0.53) | TGFBR1TRPA1ROCK2TRPM8 | |
| SCHEMBL15639504 | 0.88 | TGFBR1 (0.53) | TGFBR1TRPA1ROCK2TRPM8 | |
| SCHEMBL15639865 | 0.84 | TGFBR1 (0.49) | TGFBR1TRPA1ROCK2ROCK1TRPM8 | |
| SCHEMBL15639722 | 0.83 | TGFBR1 (0.72) | TGFBR1TRPA1ROCK2ROCK1TRPM8 | |
| SCHEMBL15638153 | 0.83 | TGFBR1 (0.52) | TGFBR1TRPA1MAPKAPK2TRPM8USP7 | |
| SCHEMBL30117459 | 0.83 | TGFBR1 (0.52) | TGFBR1TRPA1MAPKAPK2TRPM8USP7 | |
| SCHEMBL15638967 | 0.83 | TGFBR1 (0.48) | TGFBR1TRPA1MEN1RAB9AKMT2A | |
| SCHEMBL28425052 | 0.82 | TGFBR1 (0.71) | TGFBR1TRPA1ROCK2ROCK1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |