Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.52 |
| ▸ | TRPA1 | O75762 | 11/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | USP7 | Q93009 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638153 | 1.00 | TGFBR1 (0.52) | TGFBR1TRPA1S1PR1TRPM8MAPKAPK2 | |
| SCHEMBL15639661 | 0.88 | TGFBR1 (0.54) | TGFBR1TRPA1S1PR1TRPM8 | |
| SCHEMBL15637975 | 0.83 | TGFBR1 (0.51) | TGFBR1TRPA1TRPM8MAPKAPK2USP7 | |
| SCHEMBL30117441 | 0.83 | TGFBR1 (0.51) | TGFBR1TRPA1TRPM8MAPKAPK2USP7 | |
| SCHEMBL15639974 | 0.82 | TRPA1 (0.52) | TGFBR1TRPA1TRPM8MAPKAPK2USP7 | |
| SCHEMBL15639722 | 0.81 | TGFBR1 (0.72) | TGFBR1TRPA1S1PR1TRPM8 | |
| SCHEMBL28425052 | 0.81 | TGFBR1 (0.71) | TGFBR1TRPA1S1PR1TRPM8 | |
| SCHEMBL15639196 | 0.80 | TGFBR1 (0.53) | TGFBR1TRPA1TRPM8 | |
| SCHEMBL15639504 | 0.80 | TGFBR1 (0.53) | TGFBR1TRPA1TRPM8 | |
| SCHEMBL15639499 | 0.80 | TGFBR1 (0.53) | TGFBR1TRPA1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |