Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.45 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.45 |
| ▸ | WNT1 | P04628 | 3/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639794 | 1.00 | TGFBR1 (0.49) | TGFBR1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL15639917 | 0.90 | JAK2 (0.49) | TGFBR1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL15639158 | 0.83 | MAP2K4 (0.49) | TGFBR1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL30117468 | 0.83 | KDR (0.47) | TGFBR1DYRK1AKMOLRRK2CLK2 | |
| SCHEMBL15639936 | 0.83 | KDR (0.47) | TGFBR1DYRK1AKMOLRRK2CLK2 | |
| SCHEMBL15639722 | 0.79 | TGFBR1 (0.72) | TGFBR1DYRK1ACLK2PIM1DAPK3 | |
| SCHEMBL15639315 | 0.79 | KMO (0.46) | TGFBR1GRM4DYRK1AKMOLRRK2 | |
| SCHEMBL28425052 | 0.78 | TGFBR1 (0.71) | TGFBR1DYRK1ACLK2PIM1DAPK3 | |
| SCHEMBL15638024 | 0.77 | TGFBR1 (0.46) | TGFBR1DYRK1AKMOLRRK2CLK2 | |
| SCHEMBL15639813 | 0.77 | TGFBR1 (0.64) | TGFBR1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |