Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 9/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638854 | 1.00 | TRPA1 (0.48) | TRPA1FGFR2FGFR1TGFBR1KDM1A | |
| SCHEMBL15638967 | 0.92 | TGFBR1 (0.48) | TRPA1FGFR2FGFR1TGFBR1FGFR3 | |
| SCHEMBL15639831 | 0.89 | FGFR1 (0.52) | TRPA1FGFR2FGFR1TGFBR1FGFR3 | |
| SCHEMBL15639317 | 0.87 | FGFR1 (0.51) | TRPA1FGFR2FGFR1TGFBR1FGFR3 | |
| SCHEMBL15639774 | 0.86 | TRPA1 (0.62) | TRPA1FGFR2FGFR1TGFBR1FGFR3 | |
| SCHEMBL30117579 | 0.84 | FGFR1 (0.51) | TRPA1FGFR2FGFR1TGFBR1KDM1A | |
| SCHEMBL15639986 | 0.84 | FGFR1 (0.51) | TRPA1FGFR2FGFR1TGFBR1KDM1A | |
| SCHEMBL16473230 | 0.83 | TGFBR1 (0.54) | TRPA1TGFBR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15639865 | 0.80 | TGFBR1 (0.49) | TRPA1TGFBR1 | |
| SCHEMBL18712037 | 0.79 | TRPA1 (0.46) | TRPA1FGFR2FGFR1TGFBR1FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | disclosed |