Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 7/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.38 |
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | LTK | P29376 | 2/20 | 0.38 |
| ▸ | GRK5 | P34947 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638699 | 1.00 | MAP4K4 (0.44) | MAP4K4TDO2RORBDHFRKDR | |
| SCHEMBL15638204 | 0.91 | MAP4K4 (0.44) | MAP4K4TDO2RORBDHFRKDR | |
| SCHEMBL15638775 | 0.87 | FEN1 (0.49) | MAP4K4KDRFLT3KITLIMK1 | |
| SCHEMBL30117485 | 0.86 | KIT (0.42) | TDO2KDRFLT3KITADORA2A | |
| SCHEMBL15638599 | 0.86 | KIT (0.42) | TDO2KDRFLT3KITADORA2A | |
| SCHEMBL15638535 | 0.82 | TGFBR1 (0.44) | MAP4K4KDRFLT3KITLIMK1 | |
| SCHEMBL30117560 | 0.77 | SCN9A (0.47) | KDRFLT3KITADORA2AADORA1 | |
| SCHEMBL15638471 | 0.77 | SCN9A (0.47) | KDRFLT3KITADORA2AADORA1 | |
| SCHEMBL15639246 | 0.77 | MAP4K4 (0.70) | MAP4K4DHFRADORA2AADORA1TGFBR1 | |
| SCHEMBL16473255 | 0.76 | MAP4K4 (0.59) | MAP4K4TDO2RORBDHFRADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |