Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638599 | 1.00 | KIT (0.42) | KITKDRFLT3EPHB4FEN1 | |
| SCHEMBL30117560 | 0.91 | SCN9A (0.47) | KITKDRFLT3EPHB4FEN1 | |
| SCHEMBL15638471 | 0.91 | SCN9A (0.47) | KITKDRFLT3EPHB4FEN1 | |
| SCHEMBL15638535 | 0.87 | TGFBR1 (0.44) | KITKDRFLT3FEN1KMO | |
| SCHEMBL15638699 | 0.86 | MAP4K4 (0.44) | KITKDRFLT3FEN1TGFBR1 | |
| SCHEMBL30117552 | 0.86 | MAP4K4 (0.44) | KITKDRFLT3FEN1TGFBR1 | |
| SCHEMBL15638775 | 0.82 | FEN1 (0.49) | KITKDRFLT3FEN1TGFBR1 | |
| SCHEMBL15638894 | 0.79 | JAK2 (0.46) | KDREPHB4FEN1KMOTGFBR1 | |
| SCHEMBL15638247 | 0.78 | DHFR (0.52) | EPHB4FEN1KMOTGFBR1ADORA2A | |
| SCHEMBL15638882 | 0.78 | TGFBR1 (0.48) | KITKDRFLT3FEN1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903978-B1 | GDF-8 INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2022-12-07 | — | — | EP | claimed |