Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23723574 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL26525969 | 0.87 | ALDH1A1 (0.48) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL23723775 | 0.87 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL23723551 | 0.86 | GRM1 (0.52) | SMN1; SMN2TSHRHTTLMNAALDH1A1 | |
| SCHEMBL30120767 | 0.86 | GRM1 (0.52) | SMN1; SMN2TSHRHTTLMNAALDH1A1 | |
| SCHEMBL1353714 | 0.83 | TSHR (0.53) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL23723660 | 0.82 | KMT2A (0.47) | SMN1; SMN2TSHRLMNAPOLBALDH1A1 | |
| SCHEMBL1356011 | 0.80 | TSHR (0.50) | SMN1; SMN2TSHRHTTLMNAPOLB | |
| SCHEMBL23723527 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2TSHRHTTLMNAMAPT | |
| SCHEMBL23723600 | 0.78 | SLC2A1 (0.45) | LMNAALDH1A1MAPTCYP17A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100015-A1 | COMBINATION THERAPY FOR TREATING MPS1 | Gain Therapeutics SA (CH) | 2022-12-14 | — | — | EP | disclosed |
| CN-115397423-A | Combination therapy for the treatment of MPS1 | 增益治疗股份有限公司 | 2022-11-25 | — | — | CN | disclosed |