Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30120729 | 0.87 | SMN1; SMN2 (0.50) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL23723574 | 0.87 | SMN1; SMN2 (0.50) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL23723775 | 0.73 | SMN1; SMN2 (0.51) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL30596268 | 0.73 | NPBWR1 (0.48) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL30120767 | 0.72 | GRM1 (0.52) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL23723551 | 0.72 | GRM1 (0.52) | ALDH1A1MAPTHPGDSMN1; SMN2TSHR | |
| SCHEMBL30596266 | 0.72 | PDE4D (0.49) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL1353714 | 0.72 | TSHR (0.53) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL1355429 | 0.71 | SMN1; SMN2 (0.51) | ALDH1A1MAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL839950 | 0.70 | SLC2A1 (0.60) | ALDH1A1MAPTHPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230140216-A1 | COMBINATION THERAPY FOR TREATING MPS1 | GAIN THERAPEUTICS SA (CH) | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230140216-A1 | COMBINATION THERAPY FOR TREATING MPS1 | IDUA, MAN2B1, GBA1 | ALDH1A1 796/4885MAPT 2501/4885HPGD 3872/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.