Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 9/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27360801 | 0.89 | PRCP (0.56) | PRCPHTR2CMEN1CYP3A4CYP2D6 | |
| SCHEMBL1724425 | 0.76 | PRCP (0.70) | PRCPSIGMAR1MEN1 | |
| SCHEMBL31374588 | 0.74 | PRCP (0.57) | PRCPHTR2CKMT2A | |
| SCHEMBL9600234 | 0.74 | PRCP (0.57) | PRCPHTR2CKMT2A | |
| SCHEMBL1738261 | 0.74 | PRCP (0.83) | PRCPHTR2CMEN1 | |
| SCHEMBL31374586 | 0.74 | PRCP (0.57) | PRCPHTR2CKMT2A | |
| SCHEMBL3865487 | 0.71 | PRCP (0.97) | PRCPMEN1 | |
| SCHEMBL26192104 | 0.71 | PRCP (0.46) | PRCPSIGMAR1CYP3A4CYP2D6 | |
| SCHEMBL28083503 | 0.71 | PRCP (0.90) | PRCPMEN1 | |
| SCHEMBL9633303 | 0.71 | GBA1 (0.42) | PRCPHTR2CSLC6A2SLC6A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4370126-A1 | SMALL MOLECULE CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) AND IKZF2 (HELIOS) DEGRADERS AND METHODS OF USE THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2024-05-22 | — | — | EP | disclosed |
| WO-2023288305-A1 | SMALL MOLECULE CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) AND IKZF2 (HELIOS) DEGRADERS AND METHODS OF USE THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-01-19 | — | — | WO | disclosed |