Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | CCNC | P24863 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766404 | 1.00 | IRAK4 (0.50) | IRAK4MAP4K4PDE4APDE4BPDE4C | |
| SCHEMBL17680365 | 0.86 | PDE4A (0.48) | IRAK4MAP4K4PDE4APDE4BPDE4C | |
| SCHEMBL3736219 | 0.83 | MAP4K4 (0.71) | IRAK4MAP4K4ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL22549000 | 0.79 | IRAK4 (0.50) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL17660499 | 0.79 | MAP4K4 (0.77) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL31362865 | 0.79 | IRAK4 (0.50) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL17203049 | 0.79 | IRAK4 (0.50) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL7505331 | 0.75 | PIN1 (0.40) | IRAK4CCNCCDK8CDKN1ACDK19 | |
| SCHEMBL730084 | 0.75 | PDE5A (0.49) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL30369707 | 0.75 | PDE5A (0.49) | IRAK4MAP4K4CCNCCDK8CDKN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4352061-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | Redx Pharma Plc (GB) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022258974-A1 | QUINAZOLINE DERIVATIVES USEFUL AS RAS INHIBITIORS | REDX PHARMA PLC (GB) | 2022-12-15 | — | — | WO | disclosed |