Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 5/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30126836 | 1.00 | MCHR1 (0.49) | MCHR1XDHSCN9AIRAK4CNR1 | |
| SCHEMBL30126942 | 1.00 | MCHR1 (0.49) | MCHR1XDHSCN9AIRAK4CNR1 | |
| SCHEMBL19089352 | 0.92 | SCN9A (0.46) | MCHR1XDHSCN9ADHFRDCPS | |
| SCHEMBL30140430 | 0.88 | HTR2C (0.37) | MCHR1XDHIRAK4HTR2CHTR2B | |
| SCHEMBL2562599 | 0.84 | KMO (0.47) | HTR2CHTR2B | |
| SCHEMBL30781076 | 0.84 | KMO (0.47) | HTR2CHTR2B | |
| SCHEMBL29915641 | 0.83 | MCHR1 (0.49) | MCHR1XDHIRAK4DHFRDCPS | |
| SCHEMBL21652826 | 0.83 | MCHR1 (0.49) | MCHR1XDHIRAK4DHFRDCPS | |
| SCHEMBL23328015 | 0.81 | HPGD (0.50) | MCHR1SCN9AP2RX4HTR2CHTR2B | |
| SCHEMBL30882116 | 0.81 | HPGD (0.50) | MCHR1SCN9AP2RX4HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |