Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 17/20 | 0.59 |
| ▸ | MET | P08581 | 17/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL885693 | 0.85 | MET (0.76) | INSRMETALK | |
| SCHEMBL886584 | 0.81 | MET (0.87) | INSRMETALK | |
| SCHEMBL2064024 | 0.79 | MET (0.88) | INSRMETALK | |
| SCHEMBL3013376 | 0.78 | MET (0.74) | INSRMETALK | |
| SCHEMBL886064 | 0.75 | MET (0.73) | INSRMETALK | |
| SCHEMBL885864 | 0.74 | MET (1.00) | INSRMET | |
| SCHEMBL885981 | 0.71 | MET (0.88) | INSRMETALK | |
| SCHEMBL2060992 | 0.70 | MET (0.74) | INSRMET | |
| SCHEMBL886179 | 0.70 | MET (0.62) | INSRMETALK | |
| SCHEMBL886231 | 0.70 | INSR (0.54) | INSRMETALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222647-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | Cephalon, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2008051547-A1 | FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS | CEPHALON, INC. (US) | 2008-05-02 | — | — | WO | disclosed |