Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30127280 | 0.92 | PDE4B (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL30125994 | 0.91 | PDE4B (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL30126933 | 0.88 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL29781273 | 0.82 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL30127470 | 0.80 | PIK3CD (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL30126349 | 0.80 | PIK3CD (0.44) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL30126000 | 0.80 | PDE4B (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL30127359 | 0.79 | PDE4B (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL25222714 | 0.77 | PDE4B (0.48) | PDE4BUSP30RORCKDM4EMEN1 | |
| SCHEMBL5564929 | 0.77 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266458-A1 | 6-HETEROCYCLOALKYL-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |