Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 8/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.51 |
| ▸ | WNT3A | P56704 | 1/20 | 0.51 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27594834 | 0.85 | HPGD (0.65) | HPGDRAB9ANPC1SMN1; SMN2CTNNB1 | |
| SCHEMBL2937879 | 0.83 | ALDH1A1 (0.51) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL21934954 | 0.82 | RAB9A (0.53) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL5335243 | 0.81 | NPC1 (0.63) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL24315702 | 0.80 | KMT2A (0.49) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL25765135 | 0.79 | KMT2A (0.49) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL5571398 | 0.78 | NPC1 (0.47) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL3523972 | 0.78 | NPC1 (0.47) | HPGDRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL9092221 | 0.78 | NPC1 (0.47) | HPGDRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL30128238 | 0.77 | CTNNB1 (0.53) | RAB9ANPC1SMN1; SMN2CTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3596074-B1 | HETEROCYCLIC DERIVATIVES FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2022-12-14 | — | — | EP | claimed |