SCHEMBL3012913

SCHEMBL3012913

O=Cc1ccc(CCCCl)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.46
LMNA P02545 2/20 0.46
MAPT P10636 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.44
CYP2A6 P11509 4/20 0.39
ALDH5A1 P51649 1/20 0.39
ABAT P80404 1/20 0.39
RAB9A P51151 1/20 0.39
ALDH3A1 P30838 1/20 0.38
ALDH1A3 P47895 1/20 0.38
CDK1 P06493 1/20 0.36
KMT2A Q03164 1/20 0.36
TYR P14679 1/20 0.35
KDM4E B2RXH2 1/20 0.35
CYP2A13 Q16696 1/20 0.35
GMNN O75496 1/20 0.35
CYP2D6 P10635 1/20 0.35
GABRA1 P14867 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3266649 0.94 ALDH1A1 (0.44) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL4024088 0.86 HSD17B10 (0.48) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL15452989 0.86 ALDH1A1 (0.47) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL5434171 0.82 ALDH1A1 (0.44) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL5429778 0.81 CYP2A6 (0.50) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL28709923 0.81 MAOB (0.40) ALDH1A1LMNAMAPTSMN1; SMN2HSD17B10
SCHEMBL219423 0.78 ALDH1A1 (0.52) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL2457708 0.78 CA2 (0.50) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL17906209 0.78 ALDH1A1 (0.42) ALDH1A1LMNAMAPTSMN1; SMN2HPGD
SCHEMBL2225297 0.78 ALDH1A1 (0.54) ALDH1A1MAPTSMN1; SMN2CYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US claimed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP claimed
EP-2640724-A1 NOVEL INDOLIZINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2013-09-25 EP disclosed
WO-2012066234-A9 NOVEL INDOLIZINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-11-01 WO disclosed
WO-2012066234-A1 NOVEL INDOLIZINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI (FR) 2012-05-24 WO disclosed
CN-101560179-B Azotic indole derivative with H3 receptor affinity and applications UNIV ZHEJIANG 2012-04-18 CN disclosed
EP-1957490-B1 NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME SANOFI AVENTIS (FR) 2010-01-06 EP disclosed
CN-101560179-A Azotic indole derivative with H3 receptor affinity and applications UNIV ZHEJIANG (CN) 2009-10-21 CN disclosed
EP-1957490-A1 NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME sanofi-aventis (FR) 2008-08-20 EP disclosed
WO-2007060318-A1 NOVEL INDOLIZINE DERIVATIVES, METHOD FOR PREPARING SAME AND THERAPEUTIC COMPOSITIONS COMPRISING SAME SANOFI-AVENTIS (FR) 2007-05-31 WO disclosed
US-4868241-A POLYVINYL ALCOHOL MODIFIED WITH BENZOIC ACID DERIVATIVE AMERICAN CYANAMID COMPANY (US) 1989-09-19 US disclosed
EP-0231922-A2 Electron beam and X-ray resists AMERICAN CYANAMID COMPANY (US) 1987-08-12 EP disclosed