Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 3/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30129873 | 0.89 | TEAD1 (0.49) | TEAD1YAP1TNNI3KMAPTTSHR | |
| SCHEMBL24788978 | 0.83 | TEAD1 (0.61) | TEAD1YAP1TNNI3KMAPTKCNH2 | |
| SCHEMBL30129838 | 0.83 | TEAD1 (0.61) | TEAD1YAP1TNNI3KMAPTKCNH2 | |
| SCHEMBL24791425 | 0.75 | TEAD1 (0.40) | TEAD1YAP1KCNH2GABRA1GABRG2 | |
| SCHEMBL24788976 | 0.73 | TEAD1 (0.75) | TEAD1YAP1TNNI3KTSHRL3MBTL1 | |
| SCHEMBL24788980 | 0.71 | TEAD1 (0.66) | TEAD1YAP1TNNI3KMAPT | |
| SCHEMBL30135282 | 0.71 | TEAD1 (0.66) | TEAD1YAP1TNNI3KMAPT | |
| SCHEMBL22718190 | 0.68 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTTSHR | |
| SCHEMBL29438880 | 0.68 | TEAD1 (0.77) | TEAD1YAP1TNNI3KMAPTTSHR | |
| SCHEMBL24879934 | 0.67 | TEAD1 (0.42) | TEAD1YAP1TNNI3KMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115466243-A | Heterocyclic compounds for TEAD inhibitors | 武汉人福创新药物研发中心有限公司 | 2022-12-13 | — | — | CN | disclosed |