Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30130048 | 0.81 | SMN1; SMN2 (0.56) | PDGFRBFLT3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL25677972 | 0.81 | KDM4A (0.54) | ALDH1A1CYP1A2SMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL30469092 | 0.81 | KDM4A (0.54) | ALDH1A1CYP1A2SMN1; SMN2HDAC1HDAC2 | |
| SCHEMBL24510730 | 0.80 | PTPN1 (0.53) | MAOAMAOBSMN1; SMN2HDAC1PTPN1 | |
| SCHEMBL596575 | 0.78 | HDAC1 (0.67) | MAOBSMN1; SMN2HDAC1NPC1RAB9A | |
| SCHEMBL22111129 | 0.78 | PDGFRB (0.66) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL29783684 | 0.78 | PDGFRB (0.66) | KDM4EALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL853596 | 0.78 | KDM4E (0.62) | MAOAMAOBKDM4EALDH1A1CYP1A2 | |
| SCHEMBL30130020 | 0.78 | SMN1; SMN2 (0.48) | KDM4EALDH1A1HPGDPDGFRBPDGFRA | |
| SCHEMBL19964551 | 0.78 | SMN1; SMN2 (0.55) | FLT3SMN1; SMN2HDAC1HDAC2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124399-A1 | NOVEL INDOLE DERIVATIVE, AND USE THEREOF FOR TREATING DISEASES RELATED TO ADVANCED GLYCATION END PRODUCTS | METACEN THERAPEUTICS (KR) | 2024-04-18 | — | — | US | disclosed |
| EP-4353710-A1 | NOVEL INDOLE DERIVATIVE, AND USE THEREOF FOR TREATING DISEASES RELATED TO ADVANCED GLYCATION END PRODUCTS | Metacen Therapeutics (KR) | 2024-04-17 | — | — | EP | disclosed |
| WO-2022260491-A1 | NOVEL INDOLE DERIVATIVE, AND USE THEREOF FOR TREATING DISEASES RELATED TO ADVANCED GLYCATION END PRODUCTS | 주식회사 메타센테라퓨틱스 | 2022-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124399-A1 | NOVEL INDOLE DERIVATIVE, AND USE THEREOF FOR TREATING DISEASES RELATED TO ADVANCED GLYCATION END PRODUCTS | AGER, IDO1, IDO2 | MAOA 54/4885MAOB 124/4885KDM4E 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.