Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRAP1 | Q12931 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27200165 | 1.00 | TRAP1 (0.53) | TRAP1HIF1ACHRNA7IGF1RALOX15 | |
| SCHEMBL30132759 | 0.98 | TRAP1 (0.55) | TRAP1HIF1ACHRNA7IGF1RALOX15 | |
| Bromide SCHEMBL9442232 | 0.80 | HIF1A (0.54) | TRAP1HIF1A | |
| Bromide SCHEMBL10996214 | 0.80 | HIF1A (0.54) | TRAP1HIF1A | |
| Bromide SCHEMBL15766394 | 0.80 | HIF1A (0.54) | TRAP1HIF1A | |
| Bromide SCHEMBL29040474 | 0.79 | IGF1R (0.63) | TRAP1IGF1RALOX15 | |
| Bromide SCHEMBL30457991 | 0.79 | IGF1R (0.63) | TRAP1IGF1RALOX15 | |
| Bromide SCHEMBL27200194 | 0.78 | TRAP1 (0.64) | TRAP1 | |
| Bromide SCHEMBL30132765 | 0.78 | TRAP1 (0.64) | TRAP1 | |
| Bromide SCHEMBL3042031 | 0.78 | HIF1A (0.56) | TRAP1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769559-A | TRAP1 inhibitors and uses thereof | 斯玛特恩生物公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2022265178-A1 | TRAP1 INHIBITOR AND USE THEREOF | 주식회사 스마틴바이오 | 2022-12-22 | — | — | WO | disclosed |