SCHEMBL30134833

SCHEMBL30134833

O=Cc1cccnc1Oc1ccccc1OCc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNB2 O95067 1/20 0.51
CDK1 P06493 1/20 0.51
CDK4 P11802 1/20 0.51
CCNB1 P14635 1/20 0.51
CCND1 P24385 1/20 0.51
CCNB3 Q8WWL7 1/20 0.51
LTA4H P09960 1/20 0.50
MAPK14 Q16539 1/20 0.50
ERN1 O75460 1/20 0.44
LIPE Q05469 1/20 0.44
MAPT P10636 1/20 0.44
MAPK1 P28482 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
PTGER1 P34995 1/20 0.44
PTGER4 P35408 1/20 0.44
PTGER3 P43115 1/20 0.44
PTGER2 P43116 1/20 0.44
PPIA P62937 2/20 0.43
SRC P12931 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24631619 1.00 CCNB2 (0.51) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL4035249 0.85 CCNB2 (0.47) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL16632655 0.82 CCNB2 (0.59) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL24631752 0.80 LTA4H (0.53) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL30134722 0.80 LTA4H (0.53) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL29537861 0.78 CCNB2 (0.72) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL433401 0.78 CCNB2 (0.72) CCNB2CDK1CDK4CCNB1CCND1
Fluoride SCHEMBL27920182 0.77 CCNB2 (0.70) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL24631587 0.77 CCNB2 (0.47) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL24631388 0.77 CCNB2 (0.47) CCNB2CDK1CDK4CCNB1CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4319738-A1 TAAR1 AND SEROTONIN MODULATORS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Sunovion Pharmaceuticals Inc. (US) 2024-02-14 EP disclosed
CN-117279632-A TAAR1 and serotonin modulators, pharmaceutical compositions thereof, and methods of use 赛诺维信制药公司 2023-12-22 CN disclosed
WO-2022217265-A1 TAAR1 AND SEROTONIN MODULATORS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2022-10-13 WO disclosed