SCHEMBL30134837

SCHEMBL30134837

O=Cc1ccncc1Oc1ccccc1OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNB2 O95067 1/20 0.47
CDK1 P06493 1/20 0.47
CDK4 P11802 1/20 0.47
CCNB1 P14635 1/20 0.47
CCND1 P24385 1/20 0.47
CCNB3 Q8WWL7 1/20 0.47
ALDH1A1 P00352 3/20 0.45
POLB P06746 1/20 0.45
ABCB1 P08183 1/20 0.45
LMNA P02545 3/20 0.44
HTT P42858 2/20 0.44
HTR1A P08908 1/20 0.43
DRD2 P14416 1/20 0.43
SGMS2 Q8NHU3 1/20 0.43
LTA4H P09960 1/20 0.42
MAPK14 Q16539 1/20 0.42
SRC P12931 1/20 0.42
SMN1; SMN2 Q16637 3/20 0.41
HPGD P15428 1/20 0.41
THRB P10828 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24631388 1.00 CCNB2 (0.47) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL7054278 0.90 CCNB2 (0.49) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL24631587 0.89 CCNB2 (0.47) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL16632655 0.84 CCNB2 (0.59) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL9586812 0.81 CCNB2 (0.53) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL15065176 0.80 HTR1A (0.50) ALDH1A1POLBLMNAHTTHTR1A
SCHEMBL2513030 0.78 SMN1; SMN2 (0.59) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL30150617 0.77 ABCB1 (0.54) ALDH1A1POLBABCB1LMNAHTT
SCHEMBL433401 0.77 CCNB2 (0.72) CCNB2CDK1CDK4CCNB1CCND1
SCHEMBL29537861 0.77 CCNB2 (0.72) CCNB2CDK1CDK4CCNB1CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4319738-A1 TAAR1 AND SEROTONIN MODULATORS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Sunovion Pharmaceuticals Inc. (US) 2024-02-14 EP disclosed
WO-2022217265-A1 TAAR1 AND SEROTONIN MODULATORS, AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF SUNOVION PHARMACEUTICALS INC. (US) 2022-10-13 WO disclosed