Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 1/20 | 0.45 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | PRKCI | P41743 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28994444 | 0.85 | PKM (0.45) | PKMMAP2K1PRKCIAXLMAPK1 | |
| SCHEMBL22553986 | 0.84 | MAP2K1 (0.56) | PKMMAP2K1AXLJAK2JAK3 | |
| SCHEMBL30365873 | 0.84 | MAP2K1 (0.56) | PKMMAP2K1AXLJAK2JAK3 | |
| SCHEMBL23610513 | 0.84 | PRKCI (0.45) | PKMMAP2K1PRKCIAXLMAPK1 | |
| SCHEMBL857339 | 0.83 | PKM (0.42) | PKMMAP2K1PRKCIAXLMAPK1 | |
| SCHEMBL12146879 | 0.82 | MAP3K7 (0.46) | MAP3K7TAB1MAP2K1PRKCIAXL | |
| SCHEMBL1839435 | 0.81 | LRRK2 (0.51) | MAP3K7TAB1PKMMAP2K1PRKCI | |
| SCHEMBL2989355 | 0.78 | CCNT1 (0.50) | MAP3K7TAB1MAP2K1CDK2CDK9 | |
| SCHEMBL21678385 | 0.78 | PKM (0.53) | MAP3K7TAB1PKMMAP2K1PRKCI | |
| SCHEMBL31070084 | 0.78 | PKM (0.53) | MAP3K7TAB1PKMMAP2K1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250243196-A1 | CITRON KINASE INHIBITORS | THE CLEVELAND CLINIC FOUNDATION | 2025-07-31 | — | — | US | disclosed |
| WO-2022216717-A1 | CITRON KINASE INHIBITORS | THE CLEVELAND CLINIC FOUNDATION (US) | 2022-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250243196-A1 | CITRON KINASE INHIBITORS | CHEK2, CILK1, DCK | MAP3K7 15/4885TAB1 771/4885PKM 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.