Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.37 |
| ▸ | SYK | P43405 | 3/20 | 0.37 |
| ▸ | STK16 | O75716 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3013570 | 1.00 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6GSK3B | |
| SCHEMBL3020663 | 0.94 | HDAC3 (0.44) | HDAC3HDAC1HDAC2HDAC6GSK3B | |
| SCHEMBL3020670 | 0.94 | HDAC3 (0.44) | HDAC3HDAC1HDAC2HDAC6GSK3B | |
| SCHEMBL3034086 | 0.89 | LMNA (0.33) | SRCJAK2 | |
| SCHEMBL3034075 | 0.89 | LMNA (0.33) | SRCJAK2 | |
| SCHEMBL13219929 | 0.88 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6GSK3B | |
| SCHEMBL3655965 | 0.88 | GSK3B (0.39) | HDAC3HDAC1HDAC2HDAC6GSK3B | |
| SCHEMBL3026134 | 0.82 | LMNA (0.35) | HDAC3HDAC1HDAC2HDAC6SRC | |
| SCHEMBL3026142 | 0.82 | LMNA (0.35) | HDAC3HDAC1HDAC2HDAC6SRC | |
| SCHEMBL3658064 | 0.81 | HDAC3 (0.42) | HDAC3HDAC1HDAC2HDAC6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212309-B1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-19 | — | — | EP | disclosed |
| EP-2212309-B1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-19 | — | — | EP | disclosed |
| US-8440701-B2 | Trisubstituted 1,2,4 triazoles | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-14 | — | — | US | disclosed |
| US-8440701-B2 | Trisubstituted 1,2,4 triazoles | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-14 | — | — | US | disclosed |
| US-8440701-B2 | Trisubstituted 1,2,4 triazoles | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-14 | — | — | US | disclosed |
| US-20100216846-A1 | TRISUBSTITUTED 1,2,4 TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216846-A1 | TRISUBSTITUTED 1,2,4 TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-26 | — | — | US | disclosed |
| US-20100216846-A1 | TRISUBSTITUTED 1,2,4 TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-26 | — | — | US | disclosed |
| WO-2009050186-A1 | TRISUBSTITUTED 1,2,4-TRIAZOLES | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216846-A1 | TRISUBSTITUTED 1,2,4 TRIAZOLES | CHRNA1, CHRNA5, CHRNB1 | HDAC3 388/4885HDAC1 733/4885HDAC2 901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.