Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.41 |
| ▸ | HTR1A | P08908 | 8/20 | 0.41 |
| ▸ | HTR7 | P34969 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25821980 | 0.88 | DDB1 (0.44) | CRBNHTR1AHTR7DRD2DDB1 | |
| SCHEMBL30135745 | 0.88 | DDB1 (0.44) | CRBNHTR1AHTR7DRD2DDB1 | |
| SCHEMBL25031321 | 0.82 | HTR1A (0.49) | CRBNHTR1AHTR7DDB1ADAMTS5 | |
| SCHEMBL30136072 | 0.81 | TSHR (0.41) | CRBNHTR1AHTR7DRD2DDB1 | |
| SCHEMBL30135799 | 0.81 | CRBN (0.51) | CRBNDRD2DDB1MAPK1CHRM4 | |
| SCHEMBL31127674 | 0.79 | CRBN (0.49) | CRBNHTR1ADRD2 | |
| SCHEMBL25819151 | 0.79 | DDB1 (0.45) | CRBNHTR1AHTR7DRD2DDB1 | |
| SCHEMBL30822462 | 0.77 | DDB1 (0.51) | CRBNHTR1AHTR7DDB1TMEM97 | |
| SCHEMBL30135838 | 0.76 | DDB1 (0.51) | CRBNHTR1AHTR7DRD2DDB1 | |
| SCHEMBL25034990 | 0.76 | DDB1 (0.45) | CRBNDRD2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |