Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 6/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25035205 | 0.86 | KCNA3 (0.44) | HTR7HTR1ADDB1CRBNDRD2 | |
| SCHEMBL25301724 | 0.85 | HTR7 (0.49) | HTR7HTR1ADDB1CRBNDRD2 | |
| SCHEMBL30135835 | 0.81 | CRBN (0.41) | HTR7HTR1ADDB1CRBNCHRM4 | |
| SCHEMBL25035204 | 0.79 | HTR7 (0.50) | HTR7HTR1ADDB1CRBNALDH1A1 | |
| SCHEMBL30136034 | 0.78 | CRBN (0.44) | TSHRMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30135773 | 0.77 | MAPT (0.49) | TSHRL3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL25033926 | 0.77 | DDB1 (0.42) | HTR7HTR1ADDB1CRBNDRD2 | |
| SCHEMBL25824644 | 0.77 | DDB1 (0.42) | HTR7DDB1CRBNDRD2 | |
| SCHEMBL25300532 | 0.76 | HTR7 (0.42) | HTR7HTR1ASMN1; SMN2DDB1CRBN | |
| SCHEMBL31127674 | 0.74 | CRBN (0.49) | HTR1AMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |