Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.63 |
| ▸ | BRD4 | O60885 | 2/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.63 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.49 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30136097 | 0.92 | PLK1 (0.67) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL25823943 | 0.90 | PLK1 (0.65) | PLK1BRD4BRDTRAD52ALK | |
| SCHEMBL30135711 | 0.89 | PLK1 (0.71) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30135796 | 0.88 | PLK1 (0.79) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30135781 | 0.88 | PLK1 (0.67) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL25035160 | 0.87 | PLK1 (0.68) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30135971 | 0.85 | PLK1 (0.72) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30135750 | 0.85 | PLK1 (0.62) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30135899 | 0.83 | PLK1 (0.50) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL1560737 | 0.83 | PLK1 (0.76) | PLK1BRD4BRDTPLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157849-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023018238-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |