Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.48 |
| ▸ | BRD4 | O60885 | 6/20 | 0.48 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 5/20 | 0.41 |
| ▸ | PLK2 | Q9NYY3 | 4/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | PDXK | O00764 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | NEK3 | P51956 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.41 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | NEK4 | P51957 | 1/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.40 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30135899 | 0.90 | PLK1 (0.50) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30501285 | 0.90 | PLK1 (0.52) | PLK1BRD4BRDTMAPK7NUAK1 | |
| SCHEMBL25935215 | 0.89 | PLK1 (0.49) | PLK1BRD4BRDTMAPK7NUAK1 | |
| SCHEMBL25031450 | 0.86 | PLK1 (0.52) | PLK1BRD4BRDTPTK2MAPK7 | |
| SCHEMBL30501278 | 0.86 | PLK1 (0.52) | PLK1BRD4BRDTPTK2MAPK7 | |
| SCHEMBL30135959 | 0.85 | PLK1 (0.54) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL25031454 | 0.84 | PLK1 (0.45) | PLK1BRD4BRDTNUAK1 | |
| SCHEMBL30135865 | 0.83 | PLK1 (0.57) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30135711 | 0.81 | PLK1 (0.71) | PLK1BRD4BRDTPLK3PLK2 | |
| SCHEMBL30501271 | 0.80 | PLK1 (0.54) | PLK1BRD4BRDTPLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157850-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023018236-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |