Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | AHR | P35869 | 2/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789155 | 0.81 | NR3C1 (0.53) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL1018276 | 0.81 | AR (0.53) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL30136554 | 0.81 | AR (0.53) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL593678 | 0.81 | NR3C1 (0.62) | NR3C1PGRNR3C2ARAHR | |
| Hydrochloric Acid SCHEMBL27765603 | 0.79 | NR3C1 (0.51) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL28322905 | 0.79 | NR3C1 (0.51) | NR3C1PGRNR3C2ARAHR | |
| Hydrochloric Acid SCHEMBL26614912 | 0.79 | AR (0.51) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL3792302 | 0.77 | NR3C1 (0.53) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL4485961 | 0.77 | NR3C1 (0.57) | NR3C1PGRNR3C2ARAHR | |
| SCHEMBL25599218 | 0.77 | NR3C1 (0.53) | NR3C1PGRNR3C2ARAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117616028-A | 2, 8-dihydropyrazolo [3,4-B ] indole derivatives for the treatment of cancer | 默克专利股份公司 | 2024-02-27 | — | — | CN | disclosed |
| WO-2023250157-A9 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2024-01-25 | — | — | WO | disclosed |
| WO-2023250157-A1 | INHIBITORS OF MYCOBACTERIUM TUBERCULOSIS LIPOAMIDE DEHYDROGENASE | CORNELL UNIVERSITY (US) | 2023-12-28 | — | — | WO | disclosed |
| CN-117157299-A | Tricyclic heterocyclic derivative, composition and application thereof | 北京丹擎医药科技有限公司 | 2023-12-01 | — | — | CN | disclosed |
| CN-116589459-A | Apoptosis inducer | 重庆复创医药研究有限公司 | 2023-08-15 | — | — | CN | disclosed |
| CN-110546151-B | Apoptosis inducer | 重庆复创医药研究有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-115515959-A | Tricyclic heterocycles as TEAD binders | 默克专利股份公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-110121499-B | (aza) indole-, benzothiophene-and benzofuran-3-sulfonamides | 优时比制药有限公司 | 2022-12-20 | — | — | CN | disclosed |