Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | XBP1 | P17861 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Graveolide SCHEMBL31279270 | 1.00 | PTGS2 (0.59) | PTGS2MAPTRAB9ANPC1XBP1 | |
| SCHEMBL30402377 | 0.82 | MAPT (0.55) | PTGS2MAPTRAB9ANPC1XBP1 | |
| Pseudoguaianolide SCHEMBL31387995 | 0.75 | PTGS2 (0.55) | PTGS2MAPTRAB9ANPC1XBP1 | |
| Burrodin SCHEMBL30072218 | 0.74 | PTGS2 (1.00) | PTGS2MAPTRAB9ANPC1XBP1 | |
| SCHEMBL31626700 | 0.74 | PTGS2 (0.59) | PTGS2MAPTRAB9ANPC1XBP1 | |
| SCHEMBL28044817 | 0.74 | PTGS2 (0.59) | PTGS2MAPTRAB9ANPC1XBP1 | |
| Aromaticin SCHEMBL23601536 | 0.73 | MAPT (1.00) | PTGS2MAPTRAB9ANPC1XBP1 | |
| Carpesiolin SCHEMBL10099626 | 0.73 | MAPT (0.59) | PTGS2MAPTRAB9ANPC1XBP1 | |
| Carpesiolin SCHEMBL21214080 | 0.73 | MAPT (0.59) | PTGS2MAPTRAB9ANPC1XBP1 | |
| Aromaticin SCHEMBL22198794 | 0.73 | MAPT (1.00) | PTGS2MAPTRAB9ANPC1XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115477611-B | MRGPRX2 antagonists for the treatment of pseudoallergy | 香港大学 | 2024-11-08 | — | — | CN | disclosed |
| US-20220401435-A1 | MRGPRX2 ANTAGONIST FOR THE TREATMENT OF PSEUDO ALLERGIC REACTIONS | THE UNIVERSITY OF HONG KONG | 2022-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220401435-A1 | MRGPRX2 ANTAGONIST FOR THE TREATMENT OF PSEUDO ALLERGIC REACTIONS | MRGPRX2, MRGPRX1, MRGPRX4 | PTGS2 95/4885MAPT 4138/4885RAB9A 1773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.