Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140107 | 0.87 | EGFR (0.39) | GPR119EGFRKDRFGFR1FLT1 | |
| SCHEMBL30140353 | 0.86 | KDR (0.44) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL30140272 | 0.85 | EGFR (0.37) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL23538163 | 0.84 | EGFR (0.45) | EGFRKDRFLT1EPHA2EPHB4 | |
| SCHEMBL23538160 | 0.84 | EGFR (0.45) | EGFRKDRFLT1EPHA2EPHB4 | |
| SCHEMBL30140375 | 0.84 | GPR119 (0.38) | GPR119EGFRKDRFGFR1FLT1 | |
| SCHEMBL30140412 | 0.82 | KDR (0.43) | GPR119EGFRKDRFGFR1FLT1 | |
| SCHEMBL30140086 | 0.81 | EGFR (0.35) | GPR119TBK1EGFRKDRFGFR1 | |
| SCHEMBL30140394 | 0.79 | EGFR (0.61) | EGFREPHB4 | |
| SCHEMBL30140076 | 0.79 | EPHA2 (0.42) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266426-A1 | 6-(HETEROCYCLOALKYL-OXY)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |