SCHEMBL30140976

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(N)nc(F)nc43)C(OC(=O)CCC(=O)O)C2O[Si](C)(C)C(C)(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 6)

	gene	UniProt	supporting neighbours	confidence
▸	TYMP	P19971	5/20	0.47

▸	ADORA1	P30542	2/20	0.42

▸	NT5E	P21589	11/20	0.40

▸	CA5A	P35218	1/20	0.39

▸	LMNA	P02545	1/20	0.38

▸	HIF1A	Q16665	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL30141046	0.97	TYMP (0.47)	TYMPADORA1NT5ECA5ALMNA
SCHEMBL30140966	0.92	TYMP (0.50)	TYMPADORA1NT5ECA5ALMNA
SCHEMBL30140969	0.90	TYMP (0.50)	TYMPADORA1NT5E
SCHEMBL7746133	0.87	TYMP (0.56)	TYMPADORA1NT5ECA5ALMNA
SCHEMBL7896974	0.87	TYMP (0.56)	TYMPADORA1NT5ECA5ALMNA
SCHEMBL23630122	0.82	TYMP (0.51)	TYMPADORA1NT5E
SCHEMBL31075613	0.82	TYMP (0.51)	TYMPADORA1NT5E
SCHEMBL30140978	0.82	TYMP (0.45)	TYMPADORA1NT5ECA5A
SCHEMBL20334130	0.82	TYMP (0.49)	TYMPNT5ELMNA
SCHEMBL7615063	0.81	TYMP (0.59)	TYMPADORA1NT5ECA5ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4370136-A2	SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES	Alnylam Pharmaceuticals, Inc. (US)	2024-05-22	—	—	EP	disclosed
WO-2023288045-A2	SIMPLE CHEMICAL APPROACHES TO INTRODUCE 2,6-DIAMINOPURINE AND 2-AMINOADENINE CONJUGATES INTO OLIGONUCLEOTIDES	ALNYLAM PHARMACEUTICALS, INC. (US)	2023-01-19	—	—	WO	disclosed