Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24906387 | 1.00 | CRHR1 (0.41) | CRHR1NR3C1RIPK1AKR1C3AKR1C2 | |
| SCHEMBL24757816 | 0.87 | NR3C1 (0.40) | CRHR1NR3C1AKR1C3AKR1C2 | |
| SCHEMBL30106989 | 0.87 | NR3C1 (0.40) | CRHR1NR3C1AKR1C3AKR1C2 | |
| SCHEMBL30141383 | 0.86 | NR3C1 (0.42) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24757325 | 0.86 | NR3C1 (0.42) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24758991 | 0.86 | CRHR1 (0.37) | CRHR1NR3C1 | |
| SCHEMBL24757796 | 0.86 | NR3C1 (0.37) | CRHR1NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24758985 | 0.85 | ANO1 (0.46) | NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24906354 | 0.83 | CRHR1 (0.36) | CRHR1NR3C1AKR1C3AKR1C2 | |
| SCHEMBL24759017 | 0.83 | AKR1C3 (0.45) | NR3C1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | claimed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | claimed |
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |