Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30141514 | 0.90 | KDM4E (0.31) | KDM4EALDH1A1HPGD | |
| SCHEMBL30141538 | 0.87 | KDM4E (0.32) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL24906254 | 0.86 | KDM4E (0.33) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL24758326 | 0.81 | KMT2A (0.34) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL24906208 | 0.81 | KDM4E (0.32) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL30976103 | 0.81 | KDM4E (0.33) | KDM4EALDH1A1HPGDSLC5A1SLC5A2 | |
| SCHEMBL27417561 | 0.79 | KDM4E (0.33) | KDM4EALDH1A1HPGDMAPTKMT2A | |
| SCHEMBL30958823 | 0.79 | ALDH1A1 (0.33) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL27243079 | 0.77 | KDM4E (0.33) | KDM4EALDH1A1HPGDMAPTPOLB | |
| SCHEMBL30975933 | 0.76 | KDM4E (0.35) | KDM4EALDH1A1HPGDSLC5A1SLC5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4355733-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2024-04-24 | — | — | EP | disclosed |
| WO-2022263498-A1 | SUBSTITUTED PYRAZOLE AMIDES | Grünenthal GmbH (DE) | 2022-12-22 | — | — | WO | disclosed |