Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.44 |
| ▸ | KDM4A | O75164 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.44 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.44 |
| ▸ | TET3 | O43151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552004 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL31222658 | 1.00 | CYP1A2 (0.48) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL10305355 | 0.94 | CYP1A2 (0.43) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL14547871 | 0.94 | CYP1A2 (0.43) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL10830109 | 0.91 | CYP1A2 (0.45) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL18752953 | 0.90 | CYP1A2 (0.45) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL22821452 | 0.90 | CYP1A2 (0.45) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL28297074 | 0.90 | CYP1A2 (0.43) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL25137272 | 0.89 | ALB (0.43) | CYP1A2CYP2C19TET2KDM4AKDM4C | |
| SCHEMBL21447656 | 0.89 | ALB (0.43) | CYP1A2CYP2C19TET2KDM4AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240335453-A1 | METALLO-ß-LACTAMASE INHIBITORS | UNIVERSITY OF KWAZULU-NATAL (ZA) | 2024-10-10 | — | — | US | claimed |
| US-20240335453-A1 | METALLO-ß-LACTAMASE INHIBITORS | UNIVERSITY OF KWAZULU-NATAL (ZA) | 2024-10-10 | — | — | US | disclosed |
| EP-4377321-A1 | METALLO-?-LACTAMASE INHIBITORS | University of KwaZulu-Natal (ZA) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007325-A1 | METALLO-β-LACTAMASE INHIBITORS | UNIVERSITY OF KWAZULU-NATAL (ZA) | 2023-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240335453-A1 | METALLO-ß-LACTAMASE INHIBITORS | AOC1, CMBL, MANBA | CYP1A2 455/4885CYP2C19 495/4885TET2 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.