Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23489650 | 1.00 | PDE2A (0.47) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL2588946 | 1.00 | PDE2A (0.47) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL17216071 | 1.00 | PDE2A (0.47) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL29959441 | 0.85 | PDE2A (0.59) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL10553613 | 0.85 | PDE2A (0.59) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL23212834 | 0.85 | PDE2A (0.59) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL17215540 | 0.85 | PDE2A (0.59) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL423349 | 0.82 | KCNH2 (0.45) | KCNH2HTR2ASLC6A4PSEN1PSEN2 | |
| SCHEMBL16950756 | 0.80 | KCNH2 (0.39) | PDE2AKCNH2HTR2ASLC6A4PSEN1 | |
| SCHEMBL265533 | 0.80 | CES2 (0.52) | PDE2AKCNH2HTR2ASLC6A4PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112119070-B | Selective JAK2 inhibitors and uses thereof | 华东理工大学 | 2023-02-17 | — | — | CN | disclosed |