Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LIG1 | P18858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22800172 | 0.86 | KDM4E (0.63) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL3798396 | 0.82 | KDM4E (0.71) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL23748139 | 0.82 | KDM4E (0.58) | KDM4ELMNAKMT2AMAPTLIG1 | |
| SCHEMBL22800165 | 0.82 | KDM4E (0.65) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL22799642 | 0.81 | KDM4E (0.61) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL2562816 | 0.81 | KDM4E (0.74) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL73449 | 0.80 | KDM4E (0.69) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL7114649 | 0.80 | LMNA (0.69) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL14157583 | 0.80 | KMT2A (0.69) | KDM4ELMNAKMT2AMAPTMEN1 | |
| SCHEMBL31265187 | 0.80 | KDM4E (0.60) | KDM4ELMNAKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515588-A | Macrocyclic ULK1/2 inhibitors | 萨克生物研究学院 | 2022-12-23 | — | — | CN | disclosed |