Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 6/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.62 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.62 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.62 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.62 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.62 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.61 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | CLK3 | P49761 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | IDH1 | O75874 | 3/20 | 0.46 |
| ▸ | CBS | P35520 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23987183 | 1.00 | CLK1 (0.62) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL30145013 | 0.77 | CLK1 (1.00) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL25590187 | 0.77 | CLK1 (0.52) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL23499923 | 0.77 | CLK1 (1.00) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL28945469 | 0.77 | CLK1 (0.54) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL30275506 | 0.76 | CLK1 (0.51) | CLK1DYRK1ADYRK1BDYRK2CLK4 | |
| SCHEMBL24904264 | 0.73 | CSNK2A2 (0.64) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL30363450 | 0.73 | CSNK2A2 (0.64) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL26094685 | 0.73 | MEN1 (0.60) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 | |
| SCHEMBL26092772 | 0.73 | MEN1 (0.73) | CLK1DYRK1ADYRK1BDYRK2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143185-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-03-08 | — | — | EP | disclosed |
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |