Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 6/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 4/20 | 0.51 |
| ▸ | CLK2 | P49760 | 4/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 4/20 | 0.51 |
| ▸ | CLK3 | P49761 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25590187 | 0.81 | CLK1 (0.52) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL30275520 | 0.76 | DYRK1A (0.60) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL29899877 | 0.76 | DYRK1A (0.60) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL23987183 | 0.76 | CLK1 (0.62) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL30145000 | 0.76 | CLK1 (0.62) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL23987070 | 0.76 | MAPT (0.56) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL30145012 | 0.76 | MAPT (0.56) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL30145008 | 0.73 | KDM4E (0.58) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL28945547 | 0.73 | KDM4E (0.58) | CLK1DYRK1ACLK4DYRK1BDYRK3 | |
| SCHEMBL4533808 | 0.73 | SMN1; SMN2 (0.56) | CLK1DYRK1ACLK4DYRK1BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143185-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-03-08 | — | — | EP | claimed |
| EP-4143185-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2023-03-08 | — | — | EP | disclosed |