Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 11/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 11/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.52 |
| ▸ | DYRK1B | Q9Y463 | 11/20 | 0.52 |
| ▸ | CLK2 | P49760 | 9/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 9/20 | 0.52 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.52 |
| ▸ | CLK3 | P49761 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | DYRK4 | Q9NR20 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145012 | 0.87 | MAPT (0.56) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL23987070 | 0.87 | MAPT (0.56) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL28945547 | 0.84 | KDM4E (0.58) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL30145008 | 0.84 | KDM4E (0.58) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL30275506 | 0.81 | CLK1 (0.51) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL25590185 | 0.81 | CLK1 (0.64) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL25212107 | 0.80 | CLK1 (0.55) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL25257875 | 0.80 | CLK1 (0.55) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL30144911 | 0.80 | CLK1 (0.55) | CLK1CLK4DYRK1ADYRK1BCLK2 | |
| SCHEMBL30144887 | 0.80 | CLK1 (0.55) | CLK1CLK4DYRK1ADYRK1BCLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | PERHA PHARMACEUTICALS (FR) | 2023-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167104-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | CLK1, CLK2, CLK3 | CLK1 1/4885CLK4 4/4885DYRK1A 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.