Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MARS2 | Q96GW9 | 8/20 | 0.52 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595826 | 1.00 | MARS2 (0.52) | MARS2ALDH1A3HSP90AA1HSP90AB1NOS1 | |
| SCHEMBL30145251 | 0.91 | MARS2 (0.54) | MARS2ALDH1A3HSP90AA1HSP90AB1NOS1 | |
| SCHEMBL20595977 | 0.91 | MARS2 (0.54) | MARS2ALDH1A3HSP90AA1HSP90AB1NOS1 | |
| SCHEMBL20595858 | 0.80 | MARS2 (0.46) | MARS2HSP90AA1HSP90AB1NOS1NOS2 | |
| SCHEMBL20596612 | 0.79 | MARS2 (0.57) | MARS2HSP90AA1HSP90AB1NOS1NOS2 | |
| SCHEMBL30145200 | 0.79 | MARS2 (0.57) | MARS2HSP90AA1HSP90AB1NOS1NOS2 | |
| SCHEMBL23391425 | 0.79 | MARS2 (0.44) | MARS2HSP90AA1HSP90AB1NOS1NOS2 | |
| SCHEMBL20596138 | 0.79 | MARS2 (0.79) | MARS2HSP90AA1HSP90AB1NOS1NOS2 | |
| SCHEMBL20595820 | 0.78 | MARS2 (0.54) | MARS2HSP90AA1HSP90AB1NOS1NOS2 | |
| SCHEMBL30145159 | 0.78 | MARS2 (0.54) | MARS2HSP90AA1HSP90AB1NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | UNIVERSITY OF WASHINGTON (US) | 2023-02-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | AARS1, EMG1, GARS1 | MARS2 12/4885ALDH1A3 1695/4885HSP90AA1 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.