Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243792 | 0.87 | MAPT (0.58) | THRBMAPTLMNATSHRALDH1A1 | |
| SCHEMBL1244659 | 0.87 | POLB (0.54) | HPGDKDM1ARCOR1THRBMAPT | |
| SCHEMBL4478667 | 0.70 | KDM1A (0.68) | KDM1ARCOR1MAPTLMNATSHR | |
| SCHEMBL1244925 | 0.68 | MAPT (0.37) | THRBMAPTTSHRTP53NPC1 | |
| SCHEMBL5130277 | 0.68 | HSD17B10 (0.38) | HPGDTHRBMAPTTSHRALDH1A1 | |
| SCHEMBL5129680 | 0.67 | NPC1 (0.37) | MAPTNPC1 | |
| SCHEMBL15746117 | 0.65 | NPC1 (0.45) | HPGDMAPTLMNATSHRALOX15 | |
| SCHEMBL30622451 | 0.65 | CCR2 (0.53) | TSHRALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL27134845 | 0.65 | BRD4 (0.37) | MAPTNPC1 | |
| SCHEMBL27035050 | 0.65 | BRD4 (0.37) | MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |