Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 12/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244925 | 0.90 | MAPT (0.37) | NPC1FEN1MAPT | |
| SCHEMBL1244659 | 0.74 | POLB (0.54) | MAPT | |
| SCHEMBL6719573 | 0.72 | GRIK1 (0.47) | NPC1ERCC5MAPT | |
| SCHEMBL3111779 | 0.72 | NPC1 (0.33) | NPC1MAPT | |
| SCHEMBL1243792 | 0.67 | MAPT (0.58) | MAPT | |
| SCHEMBL30983311 | 0.67 | NPC1 (0.38) | NPC1 | |
| SCHEMBL25254238 | 0.67 | NPC1 (0.40) | NPC1MAPT | |
| SCHEMBL25104539 | 0.67 | DGAT1 (0.39) | NPC1 | |
| SCHEMBL30147577 | 0.67 | HPGD (0.46) | NPC1MAPT | |
| SCHEMBL3028997 | 0.66 | DGAT1 (0.36) | NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | SEPRACOR INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | SEPRACOR INC. (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058395-A1 | Fused heterocyclic inhibitors of D-amino acid oxidase | DAO, DDO, AOX1 | NPC1 4688/4885FEN1 2460/4885ERCC5 3014/4885 |
| US-20080004327-A1 | FLUORO-SUBSTITUTED INHIBITORS OF D-AMINO ACID OXIDASE | DAO, DDO, AOX1 | NPC1 4332/4885FEN1 1275/4885ERCC5 3797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.