Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23537599 | 1.00 | USP30 (0.47) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL23537598 | 1.00 | USP30 (0.47) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL594396 | 0.80 | GPR119 (0.52) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL594397 | 0.80 | GPR119 (0.52) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL28834341 | 0.79 | USP30 (0.53) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL28834338 | 0.79 | USP30 (0.53) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL15178743 | 0.78 | GPR119 (0.54) | USP30GPR119PRMT5JAK2JAK1 | |
| SCHEMBL24628228 | 0.76 | USP30 (0.57) | USP30GPR119JAK2JAK1HDAC1 | |
| SCHEMBL17837770 | 0.76 | GPR119 (0.51) | GPR119PRMT5 | |
| SCHEMBL671286 | 0.76 | JAK2 (0.49) | USP30GPR119PRMT5JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022266427-A1 | 4-(ARYL-METHYL-AMINO)-QUINAZOLINE DERIVATIVES AND USES THEREOF | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | WO | disclosed |