Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | USP2 | O75604 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110081 | 0.77 | L3MBTL3 (0.49) | CYP2D6CYP3A4ALDH1A1USP2CYP2C9 | |
| SCHEMBL2633405 | 0.77 | L3MBTL3 (0.49) | CYP2D6CYP3A4ALDH1A1USP2CYP2C9 | |
| Hydrochloric Acid SCHEMBL16059731 | 0.76 | TSHR (0.50) | CYP2D6CYP3A4ALDH1A1USP2CYP2C9 | |
| SCHEMBL17484299 | 0.73 | TSHR (0.44) | CYP2D6CYP3A4ALDH1A1USP2CYP2C9 | |
| SCHEMBL4694583 | 0.71 | HRH3 (0.44) | CYP2D6CYP3A4ALDH1A1USP2CYP1A2 | |
| SCHEMBL13931106 | 0.71 | L3MBTL3 (0.44) | CYP2D6CYP3A4ALDH1A1USP2CYP1A2 | |
| SCHEMBL6646375 | 0.70 | GRIN2B (0.55) | CYP3A4ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL1426810 | 0.69 | CYP2D6 (0.82) | CYP2D6CYP3A4ALDH1A1USP2CYP2C9 | |
| SCHEMBL24718105 | 0.69 | TSHR (0.43) | CYP2D6CYP3A4ALDH1A1USP2CYP2C9 | |
| Hydrochloric Acid SCHEMBL2224880 | 0.69 | HPGD (0.54) | CYP3A4ALDH1A1HPGDMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204224-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | VERNALIS R & D LIMITED (GB) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204224-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | SCN1B, SCN2B, SCN1A | CYP2D6 1769/4885CYP3A4 2928/4885ALDH1A1 823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.