Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | USP2 | O75604 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2110081 | 1.00 | L3MBTL3 (0.49) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| Hydrochloric Acid SCHEMBL16059731 | 0.98 | TSHR (0.50) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL346460 | 0.88 | CYP2D6 (0.39) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL13931106 | 0.88 | L3MBTL3 (0.44) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL30567860 | 0.86 | L3MBTL3 (0.49) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL23063180 | 0.86 | L3MBTL3 (0.37) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL4130497 | 0.85 | L3MBTL3 (0.52) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL17484299 | 0.84 | TSHR (0.44) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL17008457 | 0.83 | ALDH1A1 (0.46) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 | |
| SCHEMBL5568091 | 0.83 | ALDH1A1 (0.46) | L3MBTL3L3MBTL1TSHRCYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158628-B2 | Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals | GRUENENTHAL GMBH (DE) | 2012-04-17 | — | — | US | disclosed |
| US-20100234387-A1 | Sulfonylated Tetrahydroazolopyrazines and their Use as Pharmaceuticals | GRUENETHAL GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234387-A1 | Sulfonylated Tetrahydroazolopyrazines and their Use as Pharmaceuticals | BDKRB1, BDKRB2, KCNB1 | L3MBTL3 4018/4885L3MBTL1 4053/4885TSHR 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.